Introduction Benfotiamine is a lipid-soluble derivative of vitamin B1 (Thiamine) and is absorbed up to 3.6 times more than water-soluble forms. Benfotiamine is a lab-made version of vitamin B1( Thiamine). Benfotiamine is a synthetic, fat-soluble, S-acyl derivative of Thiamine (vitamin B1) that is approved in some countries as a medication or dietary supplement to treat diabetic sensorimotor polyneuropathy. Benfotiamine was developed in late 1950s in Japan.Scientists are studying it to see if it might help conditions like diabetes-related nerve damage, Alzheimer's disease, and alcohol dependence. Early research into the potential benefits of benfotiamine has shown some promise.People use benfotiamine for